Vitamin E 1000 IU side effects

Albanes D, Malila N, Taylor PR, et al. Effects of supplemental alpha-tocopherol and beta-carotene on colorectal cancer: results from a controlled trial (Finland). Cancer Causes Control. 2000;11:197-205.

Ames BN. Micronutrient deficiencies: A major cause of DNA damage. Ann NY Acad Sci. 2000;889:87-106.

Babu JR, Sundravel S, Arumugam G, Renuka R, Deepa N, Sachdanandam P. Salubrious effect of vitamin C and vitamin E on tamoxifen-treated women in breast cancer with reference to plasma lipid and lipoprotein levels. Cancer Lett. 2002;151:1-5.

Bhardwaj P, Thareja S, Prakash S, Saraya A. Micronutrient antioxidant intake in patients with chronic pancreatitis. Trop Gastroenterol. 2004 Apr-Jun;25(2):69-72.

Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev. 2008 Apr 16;(2):CD007176. Review.

Cai J, Nelson KC, Wu M, Sternberg P Jr, Jones DP. Oxidative damage and protection of the RPE. Prog Retin Eye Res. 2000;19(2):205-21.

Capuron L, Moranis A, Combe N, Cousson-Gélie F, Fuchs D, De Smedt-Peyrusse V, Barberger-Gateau P, Layé S. Vitamin E status and quality of life in the elderly: influence of inflammatory processes. Br J Nutr. 2009 Nov;102(10):1390-4.

Chae CU, Albert CM, Moorthy MV, Lee IM, Buring JE. Vitamin E supplementation and the risk of heart failure in women. Circ Heart Fail. 2012;5(2):176-82.

Choi HK. Dietary risk factors for rheumatic diseases. Curr Opin Rheumatol. 2005 Mar;17(2):141-6.

Chrubasik S. Vitamin E for rheumatoid arthritis or osteoarthritis: low evidence of effectiveness. Z Rheumatol. 2003 Oct;62(5):491.

Collaborative Group of the Primary Prevention Project. Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Lancet. 2001;357:89-95.

Debreceni B, Debreceni L. Why do homocysteine-lowering B vitamin and antioxidant E vitamin supplements appear to be ineffective in the prevention of cardiovascular disease? Cardiovasc Ther. 2012;30(4):227-33.

Dutta A, Dutta SK. Vitamin E and its role in the prevention of atherosclerosis and carcinogenesis: a review. J Am Coll Nutr. 2003 Aug;22(4):258-68.

Farina N, Isaac MG, Clark AR, Rusted J, Tabet N. Vitamin E for Alzheimer's dementia and mild cognitive impairment. Cochrane Database Syst Rev. 2012;11:CD002854.

Flood A, Schatzkin A. Colorectal cancer: does it matter if you eat your fruits and vegetables? J Natl Cancer Inst. 2000;92(21):1706-7.

Fotuhi M, Zandi PP, Hayden KM, et al. Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: the Cache County Study. Alzheimers Dement. 2008;4(3):223-7.

Gomez JA, Molero X, Vaquero E, Alonso A, Salas A, Malagelada JR. Vitamin E attenuates biochemical and morphological features associated with the development of chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2004;287(1):G162-9.

Gray SL, Anderson ML, Crane PK, Breitner JC, McCormick W, Bowen JD, Teri L, Larson E. Antioxidant vitamin supplement use and risk of dementia or Alzheimer's disease in older adults. J Am Geriatr Soc. 2008 Feb;56(2):291-5.

Hamilton KL. Antioxidants and cardioprotection. Med Sci Sports Exerc. 2007 Sep;39(9):1544-53.

Heart Outcomes Prevention Evaluation Study Investigators. Vitamin E supplementation and cardiovascular events in high-risk patients. N Engl J Med. 2000;342:154-60.

Helzlsouer KJ, Huang HY, Alberg AJ, et al. Association between alpha-tocopherol, gamma-tocopherol, selenium and subsequent prostate cancer. J Natl Cancer Inst. 2000 Dec 20;92(24):2018-23.

Hernandez J, Syed S, Weiss G, Fernandes G, von Merveldt D, Troyer DA, Basler JW, Thompson IM. The modulation of prostate cancer risk with alpha-tocopherol: a pilot randomized, controlled trial. J Urol. 2005;174(2):519-22.

Jänne PA, Mayer RJ. Chemoprevention of colorectal cancer. N Engl J Med. 2000;342(26):1960-8.

Jenab M, Salvini S, van Gils CH, Brustad M, Shakya-Shrestha S, Buijsse B, et al. Dietary intakes of retinol, beta-carotene, vitamin D and vitamin E in the European Prospective Investigation into Cancer and Nutrition cohort. Eur J Clin Nutr. 2009 Nov;63 Suppl 4:S150-78.

Jialal I, Devaraj S. Scientific evidence to support vitamin E and heart disease health claim: research needs. J Nutr. 2005;135(2):348-53.

Joshi YB, Practico D. Vitamin E in aging, dementia, and Alzheimer's disease. Biofactors. 2012;38(2):90-7.

Klein EA, Thompson IM Jr, Tangen CM, et al. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2011;306(14):1549-56.

Kline K, Lawson KA, Yu W, Sanders BG. Vitamin E and cancer. Vitam Horm. 2007;76:435-61.

Krauss RM, Eckel RH, Howard B, Appel LJ, Daniels SR, Deckelbaum RJ, et al. AHA Scientific Statement: AHA Dietary guidelines Revision 2000: A statement for healthcare professionals from the nutrition committee of the American Heart Association. Circulation. 2000;102(18):2284-99.

Laight DW, Carrier MJ, Anggard EE. Antioxidants, diabetes and endothelial dysfunction. Cardiovasc Res. 2000;47:457-64.

Lippman SM, Klein EA, Goodman PJ, Lucia MS, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2009 Jan 7;301(1):39-51.

Loprinzi CL, Barton DL, Rhodes D. Management of hot flashes in breast-cancer survivors. Lancet. 2001;2:199-204.

Major JM, Yu K, Weinstein SJ, et al. Genetic variants reflecting higher vitamin e status in men are associated with reduced risk of prostate cancer. J Nutr. 2014;144(5):729-33.

Malafa MP, Neitzel LT. Vitamin E succinate promotes breast cancer tumor dormancy. J Surg Res. 2000 Sep;93(1):163-70.

Mangialasche F, Klvipelto P, et al. High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age. J Alzheimers Dis. 2010:20(4):1029-37.

Mangialasche F, Solomon A, Kareholt I, et al. Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults. Exp Gerontol. 2013;48(12):1428-35.

Masaki KH, Losonczy KG, Izmirlian G. Association of vitamin E and C supplement use with cognitive function and dementia in elderly men. Neurology. 2000;54:1265-72.

McSorley PT, Bell PM, Young IS, Atkinson AB, Sheridan B, Fee JP, McCance DR. Endothelial function, insulin action and cardiovascular risk factors in healthy adult offspring of parents with Type 2 diabetes: effect of vitamin E in a randomized, double-blind, controlled clinical trial. Diabet Med. 2005 Jun;22(6):703-10.

Meydani M. Vitamin E modulation of cardiovascular disease. Ann N Y Acad Sci. 2004 Dec;1031:271-9.

Michels KB, Giovannucci E, Joshipura KJ, et al. Prospective study of fruit and vegetable consumption and incidence of colon and rectal cancers. J Natl Cancer Inst. 2000;92:1740-52.

Naziroglu M. Simsek M, Simsek H, Aydilek N, Ozcan Z, Atilgan R. The effects of hormone replacement therapy combined with vitamins C and E on antioxidant levels and lipid profiles in postmenopausal women with type 2 diabetes. Clin Chim Acta. 2004 Jun;344(1-2):63-71.

Nishida Y, Ito S, Ohtsuki S, Yamamoto N, et al. Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease. J Biol Chem. 2009 Nov 27;284(48):33400-8.

Pace A, Giannarelli D, Galiè E, et al. Vitamin E neuroprotection for cisplatin neuropathy: a randomized, placebo-controlled trial. Neurology. 2010 Mar 2;74(9):762.

Peters U, Littman AJ, Kristal AR, Patterson RE, Potter JD, White E. Vitamin E and selenium supplementation and risk of prostate cancer in the Vitamins and lifestyle (VITAL) study cohort. Cancer Causes Control. 2007 Oct 18; [Epub ahead of print].

Pruthi S, Allison TG, Hensrud DD. Vitamin E supplementation in the prevention of coronary heart disease. Mayo Clin Proc. 2001;76:1131-6.

Roberts LJ 2nd, Oates JA, Linton MF, et al., The relationship between dose of vitamin E and suppression of oxidative stress in humans. Free Radic Biol Med. 2007 Nov 15;43(10):1388-93.

San Giovanni JP, Chew EY, Clemons TE, et al., The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22. Age-Related Eye Disease Study Research Group. Arch Ophthalmol. 2007 Sep;125(9):1225-32.

Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. N Engl J Med. 1997;336:1216-22.

Schatzkin A, Lanza E, Corle D, et al. Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. N Engl J Med. 2000;342(16):1149-55.

Schürks M, Glynn RJ, Rist PM, Tzourio C, Kurth T. Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials. BMJ. 2010;341:c5702.

Sesso HD, Buring JE, Christen WG, et al. Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA. 2008;300:2123-33.

Trottier G, Boström PJ, Lawrentschuk N, Fleshner NE. Nutraceuticals and prostate cancer prevention: a current review. Nat Rev Urol. 2009 Dec 8. [Epub ahead of print].

Wang L, Sesso HD, Glynn RJ, et al. Vitamin E and C supplementation and risk of cancer in men: posttrial follolw-up in the Physicians' Health Study II randomized trial. Am J Clin Nutr. 2014;100(3):915-23.

Weinberg PD. Analysis of the variable effect of dietary vitamin E supplements on experimental atherosclerosis. J Plant Physiol. 2005 Jul;162(7):823-33.

Yang CS, Suh N, Kong AN. Does vitamin E prevent or promote cancer? Cancer Prev Res. 2012;5(5):701-5.

Yochum LA, Folsom AR, Kushi LH. Intake of antioxidant vitamins and risk of death from stroke in postmenopausal women. Am J Clin Nutr. 2000;72:476-83.

Is 1000 IU of vitamin E too much?

Doses for oral vitamin E generally range from 50 to 1,000 IU. Experts recommend getting vitamin E mostly from food rather than supplements. The Food and Nutrition Board of the Institute of Medicine has set an upper tolerable intake level (UL) for vitamin E at 1,000 mg (1,500 IU) per day for supplemental vitamin E.

What is vitamin E 1000 IU good for?

Vitamin E supplement helps to treat and prevents diseases of the heart and blood vessels including hardening of the arteries, heart attack, chest pain, leg pain due to blocked arteries, and high blood pressure. Vitamin E supplement helps in managing diabetes and diabetic complications.

What happens if I take vitamin E daily?

You should be able to get the amount of vitamin E you need by eating a varied and balanced diet. If you take vitamin E supplements, do not take too much as this could be harmful. Taking 540mg (800 IU) or less a day of vitamin E supplements is unlikely to cause any harm.

Is vitamin E 1000 IU good for skin?

Vitamin E helps support the immune system, cell function, and skin health. It's an antioxidant, making it effective at combating the effects of free radicals produced by the metabolism of food and toxins in the environment. Vitamin E may be beneficial at reducing UV damage to skin.